When administering salbutamol to a patient with COPD, presenting with SOB, increased WOB, coughing and crackles in the lungs, is there a rick of flooding the patient's lungs? Is this something I should be taking into consideration?

My question pertains to the use of nitroglycerin in pulmonary edema. Our directive specifies the use of nitro solely for cardiogenic pulmonary edema. I recently had a patient who deteriorated and did not respond to CPAP to the point of borderline re…