Methoxyflurane & Temperature
Question# 901
In regards to the methoxyflurane study, in the protocol itself there is no stipulation for a specific cutoff regarding an increase in temperature. At which point (what tympanic temperature) should the Penthrox be discontinued?
Answer:
Thank you for your question regarding hyperthermia and the administration of methoxyflurane.
When it comes to malignant hyperthermia (MH), prevention is essential and begins with a thorough patient history. Although MH-related fever is typically severe (>40–41°C), we take a cautious approach.
If a fever above 38.5°C develops, methoxyflurane should be discontinued immediately. Please also notify the receiving hospital and submit a Patient Safety Incident Report.
In febrile patients experiencing trauma-related pain, methoxyflurane is not strictly contraindicated. However, in such cases, it is important to monitor the patient’s temperature closely. If the temperature increases by 1°C or more, stop methoxyflurane and notify the relevant parties as mentioned above.
When it comes to malignant hyperthermia (MH), prevention is essential and begins with a thorough patient history. Although MH-related fever is typically severe (>40–41°C), we take a cautious approach.
If a fever above 38.5°C develops, methoxyflurane should be discontinued immediately. Please also notify the receiving hospital and submit a Patient Safety Incident Report.
In febrile patients experiencing trauma-related pain, methoxyflurane is not strictly contraindicated. However, in such cases, it is important to monitor the patient’s temperature closely. If the temperature increases by 1°C or more, stop methoxyflurane and notify the relevant parties as mentioned above.